Mindlift®

Ashwagandha, also known as Withania Somnifera, is a root herb commonly used worldwide for its health benefits.

The active compounds found in Ashwagandha, including alkaloids, flavonoids, and steroidal lactones, are known as withanolides. Withanolides, in particular, are considered the primary active compounds in Ashwagandha and have been extensively studied in scientific research.

These active compounds have demonstrated their ability to reduce symptoms of stress, mild anxiety, and cognitive fatigue in adults. Additionally, they enhance cognitive performance, maintain general mental well-being, and promote the body's adaptation to stress.

Mindlift contains KSM-66®, an award-winning, full-spectrum Ashwagandha extract standardized to contain more than 5% withanolides, the highest amount available worldwide.

KSM-66® is produced using 'green' chemistry, a unique processing technology that doesn't involve alcohol or synthetic solvents.

Studies

1. 300 mg, twice daily of Oral Ashwagandha Root Extract KSM 66 can be used safely as an adaptogen in adults who are under stress.
   
   K. Chandrasekhar, Jyoti Kapoor, Sridhar Anishetty, (2012) Indian Journal of Psychological Medicine ,34:3 pg 255-262 2012.
    
2. A study group that received 600mg  Ashwagandha Extract KSM 66 showed a statistically significant reduction in all the components used for symptoms of stress and mild anxiety in adults. 
   
   Salve, J, Pate, S, Debnath, K, Langade, D (2019) Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomised, Placebo-controlled Clinical Study. Cureus, 11(12), e6466.
    
3. A randomised Double-Blind, Placebo Controlled revealed that daily treatment with 300 mg twice daily ashwagandha for a period of eight weeks produced significant enhancement versus placebo in a battery of cognitive performance tests. 
   
   Choudhary, D, Bhattacharyya,S , Bose, S (2017) Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Cognitive Functions. Journal of dietary supplements, 14(6), 599–612.
    
4. A systematic Review Ashwagandha extract 250 mg - 1000 mg daily improved performance on cognitive tasks and attention span.
   
   Ng, Q. X., Loke, W., Foo, N. X., Tan, W. J., Chan, H. W., Lim, D. Y., & Yeo, W. S. (2020). A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction. Phytotherapy research : PTR, 34(3), 583–590.
    

5. This 12-week, prospective, randomised, double-blind, placebo-controlled study patients received Ashwagandha root extract at a dose of 600 mg/day. Significant Increment in the alertness is witnessed at the end of the study (week 12) compared to the baseline estimations for the participants.

   Kelgane, S. B., Salve, J., Sampara, P., & Debnath, K. (2020). Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study. Cureus, 12(2), e7083.

6. A prospective, double-blind, multi-dose, placebo-controlled, crossover study Withania somnifera is capable of enhancing cognitive function. 

   Pingali, U., Pilli, R., & Fatima, N. (2014). Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants. Pharmacognosy research, 6(1), 12–18.
    

Bacopa Monnieri, an herbaceous plant native to Australia, India, and various parts of Asia, as well as North and South America, goes by several names, including water hyssop, herb of grace, and Brahmi. It is known to contain active compounds such as alkaloids, saponins, and flavonoids.

One particularly noteworthy group of compounds found in Bacopa Monnieri is bacosides, which have been extensively studied for their potential to enhance cognitive performance, mental alertness, and attention span in adults. Additionally, they are believed to promote the body's adaptation to stress and provide relief from symptoms of stress and cognitive fatigue in adults.

Mindlift includes Bacopa Monnieri in a whole plant extract with a dry concentration of 20:1, prepared in 100% water.

Studies

1. A double-blind placebo-controlled independent-group design study Bacopa Monnieri 300 mg The current finding suggests that B. monnieri may improve higher order cognitive processes. 

   Stough, C., Lloyd, J., Clarke, J., Downey, L. A., Hutchison, C. W., Rodgers, T., & Nathan, P. J. (2001). The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology, 156(4), 481–484.
    

2. A randomised double-blind placebo-controlled study on  Bacopa Monnieri 300 mg and 600 Mg daily saw improved attention span and cognitive performance in adults.

   Tong-Un, T., Piyavhatkul, N., Rangseekajee, P., Ingkaninan, K., & Vittaya-Areekul, S. (2012). Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, in Healthy Elderly Volunteers. Evidence-based complementary and alternative medicine : eCAM, 2012, 606424.
    

3. A meta-analysis of randomised controlled trials Bacopa Monnieri 150 mg - 2g per day demonstrated that Bacopa monnieri extract has the potential to improve cognitive performance, particularly on attention span. 

   Kongkeaw, C., Dilokthornsakul, P., Thanarangsarit, P., Limpeanchob, N., & Norman Scholfield, C. (2014). Meta-analysis of randomised controlled trials on cognitive effects of Bacopa monnieri extract. Journal of ethnopharmacology, 151(1), 528–535.
    

    

Panax Ginseng, commonly referred to as Asian ginseng or Korean ginseng, is a well-known adaptogenic herb that has been utilized in traditional medicine systems, particularly in East Asia, for centuries. It is renowned for its ability to enhance energy levels and reduce cognitive fatigue in adults.

Panax Ginseng contains a variety of active compounds, including ginsenosides, which are believed to be responsible for its health benefits, including the enhancement of mental endurance, cognitive performance, and attention span in adults.

Mindlift includes a concentrated extract of Panax ginseng root, with a dry concentration ratio of 10:1.

Studies

1. A Systematic Review with five studies on Panax Ginseng 500 to 2000 mg reporting significant differences in mental fatigue measures in the invention group.

   Reference:Arring, N. M., Millstine, D., Marks, L. A., & Nail, L. M. Ginseng as a Treatment for Fatigue: A Systematic Review. Journal of alternative and complementary medicine (New York, N.Y.), 24(7), 624–633.2018.

2. A review article on Panax Ginseng 400 mg saw evidence of improved performance of attention span in adults. 
   
   Kennedy, D. O., & Scholey, A. B.Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacology, biochemistry, and behavior, 75(3), 68.

Ginkgo Biloba is a deciduous tree native to China but now commonly cultivated worldwide.

Ginkgo biloba contains a complex mixture of active compounds, including flavonoids, terpenoids, and organic acids. One unique group of compounds found in Ginkgo biloba is known as ginkgolides.

Mindlift contains 64.20 mg of ginkgo flavonol glycosides and 16.20 mg of ginkgolides per dose. These active compounds are believed to be responsible for many of Ginkgo's health benefits.

Ginkgo is recognised for its ability to enhance mental endurance, cognitive performance, and attention span in adults, while also supporting the body's adaptation to stress. Additionally, Ginkgo helps reduce symptoms of stress, mild anxiety, and cognitive fatigue in adults.

Studies

1. A randomized, placebo-controlled, double-blind, multi-center trial of 120 mg or 240 mg Ginkgo per day for 4 weeks was found to be  effective in the treatment of mild anxiety symptoms. 
   
   Gavrilova, S. I., Preuss, U. W., Wong, J. W., Hoerr, R., Kaschel, R., Bachinskaya, N., & GIMCIPlus Study Group (2014). Efficacy and safety of Ginkgo biloba extract, a randomized, placebo-controlled, double-blind, multi-center trial. International journal of geriatric psychiatry, 29(10), 1087–1095.
    
2. A randomised controlled, pre-test–post-test trial of Ginkgo Biloba 120 mg per day for 6 weeks resulted in a significant decrease in symptoms of mild anxiety and mental fatigue. 
   
   Alsmadi AM, Tawalbeh LoaiIssa, Gammoh OS, et al. The effect of Ginkgo biloba and psycho-education on stress, anxiety and fatigue among refugees. Proceedings ofSingapore Healthcare. 2018;27(1):26-32.
    
3. A systematic review and a meta-analysis of randomised controlled trials found that 240 mg  of Ginkgo Biloba per day  saw positive symptoms in improved cognitive function. 
   
   Brondino, N., De Silvestri, A.,Re, S., Lanati, N., Thiemann, P.,(2013) A Systematic Review and Meta-Analysis of Ginkgo biloba. From Ancient Tradition to Modern-Day Medicine. Evidence-based complementary and alternative medicine :veCAM, 2013, 915691

Rhodiola, also known as Rhodiola rosea, is an herb native to cold regions of Europe, Asia, and North America.

Rhodiola contains a range of active compounds, including flavonoids, phenols, and rosavin, which are unique to the plant. Mindlift contains a concentrated extract of Rhodiola rosea root, providing 1mg of salidroside and 3mg of rosavin per dose.

These compounds are believed to offer a range of potential health benefits, promoting mental endurance, cognitive performance, and energy levels, while also reducing cognitive fatigue in adults.

Studies

1. A  double-blind, placebo-controlled pilot study of 100 mg Rhodiola Extract daily found the most pronounced results were seen in the improvement in mental fatigue.

   Spasov, A.A, Wikman, G. K, Mandrikov, V. B, Mironova, I.A., & Neumoin, V. V. (2000) A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students during an examination period with a repeated low-dose regimen. Phytomedicine : international journal of phytotherapy and phytopharmacology, 7(2), 85–89.

   
    

    

Cordyceps is a genus of parasitic fungi that grows on insects, particularly caterpillars. It is native to mountainous regions of Asia, including China, Tibet, and Nepal.

Cordyceps contains a complex mixture of compounds, including polysaccharides, cordycepin, and adenosine, which are unique to the fungi.

L-tyrosine is important for the production of several important functions. 

Magnesium glycinate is a specific type of magnesium supplement where magnesium is bound to glycine, an amino acid. This unique combination enhances the absorption and bioavailability of magnesium in the body and is generally gentle on the stomach. 

 Magnesium is an essential mineral involved in numerous vital processes in the body. Magnesium glycinate is a well-tolerated and effective supplement that can support various aspects of overall health and well-being, making it a popular choice for those looking to maintain optimal magnesium levels in their bodies.

Vitamins B2, B3, and B6 are all part of the B-vitamin complex and work collaboratively to support various bodily functions.

Vitamin B2, also known as riboflavin, is a water-soluble vitamin within the B-vitamin complex. It is indispensable for many processes in the body and is recognised for promoting energy levels, as well as overall health and well-being.

Vitamin B3, also known as niacin or nicotinic acid, is an essential B vitamin that plays a crucial role in various cellular processes. It is widely used to enhance energy levels and overall health and well-being.

Vitamin B6, known as pyridoxine, is involved in numerous bodily processes. Its unique chemical structure and diverse functions make it an indispensable component of human health and vitality.