NightDrift®

Magnesium Glycinate is a highly bioavailable, easily absorbed form of magnesium, bound to the calming amino acid glycine. It’s gentle on the digestive system and far less likely to cause stomach upset or laxative effects.

Magnesium plays a role in over 300 enzymatic reactions in the body and is essential for muscle function, nervous system health, stress symptom regulation, and deep, restorative sleep.

Nightdrift’s Magnesium Glycinate helps prevent dietary magnesium deficiency. No bodily system can function without it, magnesium is considered a foundational nutrient for long-term health and overall wellbeing.

Studies

1. A systematic review of randomized controlled trials found magnesium is a safe and effective supplement for reducing stress symptoms and supporting nervous system function. Studies highlight its role in modulating neurotransmitters and reducing symptoms of mild anxiety.
   Botturi, A., Ciappolino, V., Delvecchio, G., Boscutti, A., Viscardi, B., & Brambilla, P. (2020). The role and effect of magnesium in mental disorders: A systematic review. Nutrients, 12(1661).
   
   
2.  A Systematic review of randomized controlled trials and non-randomized intervention studies found that magnesium supplementation was associated with reduced anxiety symptoms in individuals with mild anxiety. Studies suggest that magnesium plays a role in nervous system function by modulating neurotransmitters and stress response pathways. 
   Boyle, N. B., Lawton, C., & Dye, L. (2017). The effects of magnesium supplementation on subjective anxiety and stress—A systematic review. Nutrients, 9(429).
   
   
3.  Magnesium supplementation appears to be beneficial for muscle relaxation and overall health in physically active individuals. A systematic review of randomized controlled trials demonstrates magnesium supplementation and its role in neuromuscular function. 
   Tarsitano, M. G., Quinzi, F., Folino, K., Greco, F., Oranges, F. P., Cerulli, C., & Emerenziani, G. P. (2024). Effects of magnesium supplementation on muscle soreness in different types of physical activities: A systematic review. Journal of Translational Medicine, 22(629).
   
   
4. Magnesium supplementation appears beneficial for muscle relaxation in populations with magnesium deficiency and plays a critical role in maintaining general health.A systematic review and meta-analysis of randomized controlled trials found evidence to support its importance in neuromuscular function.
   Wang, R., Chen, C., Liu, W., Zhou, T., Xun, P., He, K., & Chen, P. (2017). The effect of magnesium supplementation on muscle fitness: A meta-analysis and systematic review. Magnesium Research, 30(4), 120-132.
   
   
5.  This counterbalanced, double-blind, placebo-controlled study provides strong evidence that magnesium supports muscle relaxation and stress symptom reduction, particularly in endurance athletes. The findings align with broader research on magnesium’s role in neuromuscular efficiency and post-exercise recovery.
   Steward, C. J., Zhou, Y., Keane, G., Cook, M. D., Liu, Y., & Cullen, T. (2019). One week of magnesium supplementation lowers IL-6, muscle soreness, and increases post-exercise blood glucose in response to downhill running. European Journal of Applied Physiology, 119(12), 2705–2715.
   
   
6. A randomized, placebo-controlled trial on magnesium supplementation finding it  may help counteract age sleep disturbances in elderly individuals. The study found improvements in sleep quality and deep sleep, alongside modulations in stress symptoms.
   Held, K., Antonijevic, I. A., Künzel, H., Uhr, M., Wetter, T. C., Golly, I. C., Steiger, A., & Murck, H. (2002). Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry, 35(4), 135–143.
   
   
7. This systematic review found Magnesium supplementation is associated with improved sleep quality, increased total sleep time, and reductions in stress-related biomarkers. Observational studies suggested that higher dietary magnesium intake was linked to better sleep quality.
   Arab, A., Ra"e, N., Amani, R., & Shirani, F. (2022). The role of magnesium in sleep health: A systematic review of available literature. Biological Trace Element Research, 200(3), 1–13.

L-Theanine is a naturally occurring amino acid found in green tea, traditionally used to support relaxation and a calm mind. Nightdrift features AlphaWave® L-Theanine, a clinically trialled form shown to help promote a relaxed mental state.

AlphaWave L-Theanine® has been studied using EEG (electroencephalogram) technology and shown to support the production of alpha brainwaves- brain activity typically associated with calmness and peaceful wakefulness, such as during meditation.

By encouraging this alpha brainwave state, L-Theanine supports a sense of calm, helps reduce symptoms of stress, and improves sleep quality by calming the mind before bedtime making it ideal for your evening wind-down routine.

Studies

1. This randomised, double-blind, placebo-controlled showed Theanine (AlphaWave®) supplementation for 28 days was found to be safe and effective in reducing perceived stress symptoms and enhancing sleep quality in healthy adults with moderate stress. The study highlights the potential of l-Theanine to support mental relaxation and promotion of deep sleep. The decrease in light sleep suggests a potential shift towards more restorative sleep.
   
   Moulin, M., Crowley, D. C., Xiong, L., Guthrie, N., & Lewis, E. D. (2024). Safety and efficacy of Theanine (AlphaWave®) supplementation for 28 days in healthy adults with moderate stress: A randomized, double-blind, placebo-controlled trial. Neurology and Therapy, 13(4), 1135–1153.
   
   
2. A randomised, double-blind, placebo-controlled clinical found L-Theanine supplementation for four weeks was found to be safe and effective in reducing stress-related symptoms, enhancing cognitive function, and improving sleep quality in healthy adults. These findings suggest that L-Theanine can support cognitive performance, and sleep without causing adverse effects.
   
   Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: A randomized controlled trial. Nutrients, 11(10), 2362. 
   
   
3. In a placebo-controlled clinical trial, results found L-Theanine’s ability to enhance alpha brain waves, which are linked to relaxation, reducing stress symptoms and supporting nervous system function.
   
   Nobre, A. C., Rao, A., & Owen, G. N. (2008). L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific Journal of Clinical Nutrition, 17(S1), 167-168.
   
   
4. A systematic review of randomised controlled trials of L-Theanine is a safe and effective supplement for reducing stress-related symptoms, improving sleep quality, and supporting nervous system function through its ability to modulate neurotransmitter activity. 
   
   Moshfeghinia, R., Sanaei, E., Mostafavi, S., Assadian, K., Sanaei, A., & Ayano, G. (2024). The effects of L-theanine supplementation on the outcomes of patients with mental disorders: A systematic review. BMC Psychiatry, 24(886).
   
   
5. L-Theanine is a safe and effective supplement for improving sleep quality, stress symptom reduction, and nervous system function. This systematic review of randomised controlled trials highlights significant improvements in sleep duration, efficiency, and onset latency. 
   
   Innocenti, A., Lentini, G., Rapacchietta, S., Cinnirella, P., Elia, M., Ferri, R., & Bruni, O. (2023). The role of supplements and over-the-counter products to improve sleep in children: A systematic review. International Journal of Molecular Sciences, 24(7821).
   
   
6. This triple-blind, randomised, placebo-controlled, crossover trial provides direct clinical evidence supporting L-Theanine’s role in stress symptom reduction and relaxation. The statistically significant  increases in alpha wave activity reinforce L-Theanine’s effectiveness in managing stress responses.
   
   Evans, M., McDonald, A. C., Xiong, L., Crowley, D. C., & Guthrie, N. (2021). A randomized, triple-blind, placebo-controlled, crossover study to investigate the efficacy of a single dose of AlphaWave® L-Theanine on stress in a healthy adult population. Neurology and Therapy.

Chamomile (Matricaria chamomilla) is a well-known herb traditionally used in Western herbal medicine to aid mind relaxation, reduce symptoms of stress, and support healthy sleep patterns.

Its calming properties are largely attributed to a natural compound called apigenin, a plant-based flavonoid found in chamomile flowers. Apigenin is known for helping promote a sense of calm and preparing the body for rest, making chamomile an ideal part of an evening wind-down routine.

Chamomile may also help to improve sleep quality, maintain refreshing sleep, and support general health and wellbeing when used regularly as part of a healthy lifestyle.

Studies

1. In a systematic review and meta-analysis of randomised controlled trials, Chamomile appears to be a relatively safe herb for the improvement of sleep quality and mild anxiety symptoms. 
   
   Truong Hong Hieu, Mahmoud Dibas, Kadek Agus Surya Dila, Nourin Ali Sherif, Muhammad Usman Hashmi, Mostafa Mahmoud, Nguyen Thi Thuy Trang, Lava Abdullah, Thai Le Ba Nghia, Mai Nhu Y, Kenji Hirayama, Nguyen Tien Huy. (2019). Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and meta‐analysis of randomized trials and quasi‐randomized trials. Phytotherapy Research, 1-12.
   
   
2. Chamomile appears to be a safe and potentially effective natural therapy for reducing symptoms of stress and improving general well-being in a randomized controlled trial. 
   
   Mao, J. J., Xie, S. X., Keefe, J. R., Soeller, I., Li, Q. S., & Amsterdam, J. (2016). Long-term Chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Phytomedicine, 23(14), 1735–1742.
   
   
3. A systematic review and meta-analysis showed chamomile appears to be a safe and effective natural remedy for improving sleep quality, particularly by reducing sleep disturbances, improving sleep onset latency, and decreasing awakenings during the night. Additionally, better sleep quality may contribute to overall health and well-being, as poor sleep is linked to multiple health risks. 
   
   Kazemi, A., Shojaei-Zarghani, S., Eskandarzadeh, P., & Hashempur, M. H. (2024). Effects of chamomile (Matricaria chamomilla L.) on sleep: A systematic review and meta-analysis of clinical trials. Complementary Therapies in Medicine, 84, 103071.
   
   
4. Chamomile extract significantly improved sleep quality among elderly individuals, particularly in reducing sleep disturbances and enhancing overall sleep patterns. This single-blind randomized controlled study provides clinical evidence that chamomile can be used as a safe, natural alternative to improve sleep. 
   
   Adib-Hajbaghery, M., & Mousavi, S. N. (2017). The effects of chamomile extract on sleep quality among elderly people: A clinical trial. Complementary Therapies in Medicine, 35, 109–114.